What Is NAD+ and

Why It Matters

Nicotinamide adenine dinucleotide (NAD⁺) might sound like a mouthful, but it’s one of the most essential molecules in your body. Think of it as your cells’ spark plug—without it, your body can’t generate energy efficiently, and you may start to feel that slowdown in your daily life: low energy, longer recovery, and even visible signs of aging.

Let’s break down what the latest science says about NAD⁺ and why more people are turning to it for a serious wellness upgrade.

1. More Energy, Less Fatigue​

As we get older, our NAD⁺ levels naturally decline. This decline has been linked to fatigue, reduced cellular repair, and slower recovery from stress. But here’s the good news: new clinical studies are showing that replenishing NAD⁺ levels is both safe and effective.

  • Nuchido TIME+ Trial: In a double-blind study, adults who took an NAD⁺-boosting supplement saw a 26.5% increase in NAD⁺ levels—plus improvements in youth-associated proteins (like SIRT1) and reductions in inflammation.

  • Qualia NAD⁺ Study (2025): Participants experienced a 74% average boost in NAD⁺, with no serious side effects.

Bottom line: better NAD⁺ means more cellular energy, fewer sluggish days, and a shot at feeling younger from the inside out.

Nicotinamide adenine dinucleotide (NAD⁺) might sound like a mouthful, but it’s one of the most essential molecules in your body. Think of it as your cells’ spark plug—without it, your body can’t generate energy efficiently, and you may start to feel that slowdown in your daily life: low energy, longer recovery, and even visible signs of aging.

Let’s break down what the latest science says about NAD⁺ and why more people are turning to it for a serious wellness upgrade.

1. More Energy, Less Fatigue​

As we get older, our NAD⁺ levels naturally decline. This decline has been linked to fatigue, reduced cellular repair, and slower recovery from stress. But here’s the good news: new clinical studies are showing that replenishing NAD⁺ levels is both safe and effective.

  • Nuchido TIME+ Trial: In a double-blind study, adults who took an NAD⁺-boosting supplement saw a 26.5% increase in NAD⁺ levels—plus improvements in youth-associated proteins (like SIRT1) and reductions in inflammation.

  • Qualia NAD⁺ Study (2025): Participants experienced a 74% average boost in NAD⁺, with no serious side effects.

Bottom line: better NAD⁺ means more cellular energy, fewer sluggish days, and a shot at feeling younger from the inside out.

2. Better Metabolism, Better Balance

If you’re working on managing blood sugar, metabolism, or weight, NAD⁺ might be a game-changer.

  • A 2021 study found that postmenopausal women with prediabetes who took 250 mg/day of an NAD⁺ precursor (NMN) had better insulin sensitivity and activated key metabolic pathways that help your body process energy more efficiently.

In plain English: NAD⁺ helps your cells use energy better, making it easier to stay balanced and burn fuel the right way.

3. Endurance That Lasts

In a 2023 clinical trial, healthy adults who took NAD⁺ precursors (600–900 mg/day) for 60 days:

  • Walked significantly farther in a standardized endurance test

  • Reported feeling better overall

Our clients often say they recover faster after workouts and feel more resilient through the day—especially when pairing NAD⁺ with healthy habits like exercise and hydration.

4. Brain Health & Cellular Repair

While larger human trials are still ongoing, early findings are promising.

  • NAD⁺ is vital for DNA repair enzymes and nerve cell protection.

  • In lab studies, boosting NAD⁺ helped improve memory, focus, and reduced inflammation markers linked to aging and chronic illness.

This means NAD⁺ may not just make you feel sharper today—it might help your brain stay healthier tomorrow.

The Takeaway

NAD⁺ therapy isn’t a one-size-fits-all solution—but when used as part of a comprehensive wellness plan, it’s a powerful tool.

✔️ Safe & well-tolerated in clinical studies
✔️ Supports energy, metabolism, endurance, and brain repair
✔️ Works best alongside good nutrition, regular movement, and stress care

If you’re looking for a smart, science-backed way to feel more energized, focused, and balanced, our medspa team can help create a personalized NAD⁺ plan that fits your goals.

How is NAD+ Taken?

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Ready to Recharge from the Inside Out?

If you’re curious whether NAD⁺ therapy fits your wellness goals—be it more energy, better workouts, or metabolic support—our medspa team can help design a personalized plan grounded in the latest science.

Stay tuned for upcoming posts where we’ll dive into practical considerations of NAD and other anti-aging regenerative therapies. Ready to feel revitalized from the inside out?

Let’s explore NAD⁺ together!

References

  1. Henderson, J.D., Quigley, S.N.Z., Chachra, S.S. et al. The use of a systems approach to increase NAD+ in human participants. npj Aging 10, 7 (2024). https://doi.org/10.1038/s41514-023-00134-0
  2. Blomquist, S.A., Kelly, G., Adaes, S., et al, Qualia NAD+ increases NAD+ in human participants: A randomized, double-blind, placebo-controlled study. MedRXiv (preprint). https://doi.org/10.1101/2025.03.19.25324259 
  3. Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021 Jun 11;372(6547):1224-1229. doi: 10.1126/science.abe9985. Epub 2021 Apr 22. PMID: 33888596; PMCID: PMC8550608 
  4. Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2023 Feb;45(1):29-43. doi: 10.1007/s11357-022-00705-1. Epub 2022 Dec 8. PMID: 36482258; PMCID: PMC9735188 
  5. Conlon NJ. The Role of NAD+ in Regenerative Medicine. Plast Reconstr Surg. 2022 Oct 1;150(4 Suppl ):41S-48S. doi: 10.1097/PRS.0000000000009673. Epub 2021 Sep 28. PMID: 36170435; PMCID: PMC9512238
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